Endocrine Abstracts

Introduction: Paragangliomas (PGLs) are rare neuroendocrine tumors that arise from sympathetic or parasympathetic extra-adrenal paraganglia. PGLs have an extremely variable clinical presentation, depending on the localization, tumor size, catecholamine production, compressive symptoms, etc. Germline mutations in PGLs are associated in 30-35% of patients. Mutation in genes encoding the subunits of succinate dehydrogenase (SDH) leads to an increased risk of metastasis, specially...

Introduction and Objectives: Although Next Generation Sequencing (NGS) technologies have significantly improved the molecular diagnosis of MODy, there is still a high percentage of cases in which the clinical suspicion remains without confirmatory molecular diagnosis. The main objective was to identify new candidate genes for MODy, by means of targeted NGS of a cohort of adult patients with clinically suspected MODy, in whom variants in the 14 known MODy genes implicated in it...

Aim: The use of continuous subcutaneous insulin infusion (CSII) systems in type 1 diabetic patients (DM1) is progressively increasing, leading to an increase in cases in which its maintenance during hospitalization is considered. The objective of the study is to analyze the safety of glycemic control with CSII therapy during hospitalization in DM1 adults.Material and Methods: Retrospective observational study on a cohort of DM1 people hospitalized the la...

Aim: Describing bariatric surgery (BS) interventions in our center in the last five years, complications and effectiviness in weight loss and resolution of comorbities.Methodology: Prospective descriptive study on a cohort of people who underwent BS surgery at Virgen Macarena University Hospital, a tertiary hospital of the Public Health System of Andalusia, between January 2018 and May 2023. Patients who underwent revision surgery with a first previous s...

Aim: Illustrating a case series of two patients with levothyroxine malabsorption and suboptimal control of the thyroid profile who experienced a significant improvement after switching to liquid levothyroxine.Material and Methods: Case saries of two patients who were attended in monographic thyroid pathology consultations at Virgen Macarena University Hospital.Results: Case 1: a 46-year-old female patient who had multinodular goitr...

Introduction: Amiodarone-induced thyrotoxicosis (AIT) occurs in up to 6% of patients taking this medication in iodine sufficient areas and in up to 10% of patients in iodine deficient areas and has a high rate of mortality, that can reach 50% in untreated severe forms. There are two main types (1 and 2) described, although usually we find mixed types, with both components. Below, we describe the cases of two brothers that developed severe mixed forms of amiodarone-induced thyr...

The lipodystrophic syndromes are a heterogeneous group of congenital or acquired disorders characterized by either complete or partial lack of adipose tissue with the apparent accumulation of fat in other regions of the body. Their prevalence is low and ranges from 1:200000/500000 and they usually suffer metabolic abnormalities associated with the abnormal distributition of fat such as severe insulin resistance with acantosis and diabetes, progressive liver disease along with ...

Objectives: To evaluate the changes in HbA1c, basal glucose, weight, and lipid profile in patients with type 2 diabetes after starting oral semaglutide.Methods: This study was conducted in Madrid, Fundación Jiménez Díaz, Infanta Elena and General de Villalba hospitals. A total of 75 patients with type 2 diabetes were included. The mean age was 62.0±10.5 years and 60% were men. The mean duration of diabetes was 7.3±6.6 years, and 66.7...

Introduction: During gender affirming therapy in transgender men (TXM), androgens are administered at escalating doses. As therapy progresses, changes in various analytical parameters occur that may be of potential use in establishing a personalised androgen dosage and avoiding deleterious effects of the medication. The aim of our study was to study the evolution of different parameters throughout the course of gender affirming therapy.Material and metho...

Introduction: Admission hyponatremia, frequently detected in patients hospitalized for COVID-19, has been associated with increased mortality. However, although SIADH-induced euvolemic hyponatremia is the single most-common cause of hyponatremia in community-acquired pneumonia, repercussions of admission-hyponatremia volemic classification on COVID-19 hospitalizations have yet to be described. We sought to identify factors contributing to mortality and hospital length-of-stay ...